Selection of dual Vα T cells

T-dual Rickart modules

We introduce the notions of T-dual Rickart and strongly T-dual Rickart modules. We provide several characterizations and investigate properties of each of these concepts. It is shown that every free (resp. finitely generated free) $R$-module is T-dual Rickart if and only if $overline{Z}^2(R)$ is a  direct summand of $R$ and End$(overline{Z}^2(R))$ is a semisimple (resp. regular) ring. It is sho...

Dual Control of Antitumor CD8 T Cells

Self-restricted dual receptor memory T cells.

Enhanced immune responses during secondary exposure to Ag result from the development of memory cells. In the present report we show that stimulation through one receptor on dual receptor CD4 cells can promote the generation of T cells capable of giving a memory response through the second receptor, even though the cells had not been previously exposed to the Ag recognized by the second recepto...

Development and selection of gd T cells

Two main lineages of T cells develop in the thymus: those that express the ab T-cell receptor (TCR) and those that express the gd TCR. Whereas the development, selection, and peripheral localization of newly differentiated ab T cells are understood in some detail, these processes are less well characterized in gd T cells. This review describes research carried out in this laboratory and others,...

Dual T cell receptor alpha chain T cells in autoimmunity

Allelic exclusion at the T cell receptor alpha locus TCR-alpha is incomplete, as demonstrated by the presence of a number of T lymphocyte clones carrying two expressed alpha chain products. Such dual alpha chain T cells have been proposed to play a role in autoimmunity, for example, because of a second TCR-alpha beta pair having bypassed negative selection by virtue of low expression. We examin...